The papers listed here (and in the birdshot research projects section) give you more information about possible treatments for birdshot.
They may be useful
- To persuade you, if you are not already under the care of a uveitis specialist, to get yourself to a uveitis specialist who treats others with birdshot and who will oversee your treatment.
- To help you see the benefits of taking what seem to be very scary medicines in order to preserve your sight.
- To give you some idea of the treatments which work, treatments in the pipeline and the exciting world of ophthalmology research.
BUS is extremely grateful for the valuable assistance received from Dr Graham Wallace and Dr Robert Barry of Birmingham University, UK, in selecting articles for this section on relevant birdshot research.
We have divided up the research papers into several topic areas which are accessed via the drop-down menus below. Where we can link into the whole paper, we have done so, but if that is not possible, the link is to the abstract. If you are interested in reading the full paper and it is not available, please get in touch and BUS will try to assist.
BUS will continue to add links to research papers, so we would be grateful for suggestions for other papers that should be included here.
A review and update on orphan drugs for the treatment of noninfectious uveitis
January 2017
A review and update on orphan drugs for the treatment of noninfectious uveitis (full-text)
Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment
May 2016
Evangelos Minos, Robert J Barry, Sue Southworth, Annie Folkard, Philip I Murray, Jay S Duker, Pearse A Keane, Alastair K Denniston
Pharmacotherapy for uveitis: current management and emerging therapy
September 2014
Robert J Barry, Quan Dong Nguyen, Richard W Lee, Philip I Murray, Alastair K Denniston
Pharmacotherapy for uveitis: current management and emerging therapy (full-text)
Local therapies for inflammatory eye disease in translation: past, present and future
August 2013
Shenzhen Tempest-Roe, Lavnish Joshi, Andrew D Dick, Simon RJ Taylor
Local therapies for inflammatory eye disease in translation: past, present and future (full-text)
Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis
June 2013
Rushmia Karim, Evripidis Sykakis, Susan Lightman, Samantha Fraser-Bell
Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis (full-text)
The incidence, presenting clinical findings and treatment patterns of Birdshot Retinochoroiditis in a high-prevalence region: findings from Northern Ireland, England and Wales
February 2023
Rana Khalil, Harry Petrushkin, Angela Rees & Mark Westcott
HLA-A29 Birdshot Retinochoroiditis in its 5th Decade: Selected Glimpses into the Intellectual Meanderings and Progresses in the Knowledge of a Long-Time Misunderstood Disease
July 2021
Papadia M, Pavésio C, Fardeau C, Neri P, Kestelyn PG, Papasavvas I, Herbort CP
Poor prognostic factors in patients with birdshot retinochoroidopathy
November 2016
Sukhum Silpa-Archa, Joan J Lee, Sutasinee Boonsopon, Marisoll T Lizarraga, Janine M Preble, Dusi Sujirarat, Pranav Patel, C Stephen Foster
Poor prognostic factors in patients with birdshot retinochoroidopathy (abstract)
Birdshot retinochoroidopathy: prognostic factors of long-term visual outcome
October 2016
Sara Touhami, Christine Fardeau, Antoine Vanier, Olivia Zambrowski, Rafaela Steinborn, Claude Simon, Sophie Tezenas du Montcel, Bahram Bodaghi, Phuc Le Hoang
Birdshot retinochoroidopathy: prognostic factors of long-term visual outcome (abstract)
Birdshot retinochoroidopathy: differences in clinical characteristics with early and late age onset
April 2016
Sukhum Silpa-Archa, Jennifer H. Cao, Sutasinee Boonsopon, Joan Lee, Janine M. Preble, Stephen Foster
Birdshot retinochoroidopathy differences in clinical characteristics with early and late age onset (abstract)
There are several ‘quality of life’ questionnaires in existence that attempt to measure the effects of sight loss on mood and health. However, these questionnaires are not really relevant to the variable condition of birdshot uveitis with its many problems we face day to day, especially at the time of a flare or because of treatment side-effects. With the help of psychologist John Barry and ophthalmology consultant Professor Will Ayliffe, BUS designed a questionnaire for our membership to trial. In 2012, nearly 200 of our members completed this birdshot quality of life questionnaire as part of a study carried out by BUS to validate it. Below are links to the two papers that were published about this work:
Creating a Health Utility Value for Birdshot Chorioretinopathy
September 2020
Anisha Sekaran, Mohith Shamdas, Robert J Barry, Alastair K Denniston and Philip I Murray
Creating a Health Utility Value for Birdshot Chorioretinopathy (abstract)
Development and validation of quality-of-life questionnaires for birdshot chorioretinopathy
July 2014
John A Barry, Annie Folkard, Alastair K Denniston, Eileen Moran, William Ayliffe
Development and validation of quality-of-life questionnaires for birdshot chorioretinopathy (full-text)
Validation of a brief questionnaire measuring positive mindset in patients with uveitis
March 2014
John A Barry, Annie Folkard, William Ayliffe
Validation of a brief questionnaire measuring positive mindset in patients with uveitis (full-text)
“The patient is speaking”: discovering the patient voice in ophthalmology
June 2017
Samera Dean, Jonathan M Mathers, Melanie Calvert, Derek G Kyte, Dolores Conroy, Annie Folkard, Sue Southworth, Philip I Murray, Alastair K Denniston
“The patient is speaking”: discovering the patient voice in ophthalmology (full-text)
Single-cell profiling identifies a CDbright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy
July 2024
Pulak R. Nath, Mary Maclean, Vijay Nagarajan, Jung Wha Lee, Mehmet Yakin, Aman Kumar, Hadi Nadali, Brian Schmidt, Koray D. Kaya, Shilpa Kodati, Alice Young, Rachel R. Caspi, Jonas J. W. Kuiper and H. Nida Sen
Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy https://shorturl.at/gqc0l (full-text)
HLA- A29 and Birdshot Uveitis: Further down the Rabbit Hole
November 2020
Jonas JW Kuiper, Wouter J Venema
HLA-A29 and Birdshot Uveitis: Further Down the Rabbit Hole https://pubmed.ncbi.nlm.nih.gov/33262772/ (abstract)
Heterogeneity of primary outcome measures used in clinical trials of treatments for intermediate, posterior, and panuveitis
August 2015
Alastair K Denniston, Gary N Holland, Andrej Kidess, Robert B Nussenblatt, Annabelle A Okada, James T Rosenbaum, Andrew D Dick
Controversies in the pharmacological treatment of uveitis
July 2015
Robert J Barry, Alastair K Denniston
Controversies in the pharmacological treatment of uveitis (abstract)
Updated September 2024