The papers listed here (and in the birdshot research projects section) give you more information about possible treatments for birdshot.
They may be useful
- To persuade you, if you are not already under the care of a uveitis specialist, to get yourself to a uveitis specialist who treats others with birdshot and who will oversee your treatment.
- To help you see the benefits of taking what seem to be very scary medicines in order to preserve your sight.
- To give you some idea of the treatments which work, treatments in the pipeline and the exciting world of ophthalmology research.
BUS is extremely grateful for the valuable assistance received from Dr Graham Wallace and Dr Robert Barry of Birmingham University, UK, in selecting articles for this section on relevant birdshot research.
We have divided up the research papers into several topic areas which are accessed via the drop-down menus below. Where we can link into the whole paper, we have done so, but if that is not possible, the link is to the abstract. If you are interested in reading the full paper and it is not available, please get in touch and BUS will try to assist.
BUS will continue to add links to research papers, so we would be grateful for suggestions for other papers that should be included here.
▫A review and update on orphan drugs for the treatment of noninfectious uveitis
▫Pharmacotherapy for uveitis: current management and emerging therapy
Robert J Barry, Quan Dong Nguyen, Richard W Lee, Philip I Murray, Alastair K Denniston
▫Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment
Evangelos Minos, Robert J Barry, Sue Southworth, Annie Folkard, Philip I Murray, Jay S Duker, Pearse A Keane, Alastair K Denniston
▫Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis
Rushmia Karim, Evripidis Sykakis, Susan Lightman, Samantha Fraser-Bell
▫Local therapies for inflammatory eye disease in translation: past, present and future
Shenzhen Tempest-Roe, Lavnish Joshi, Andrew D Dick, Simon RJ Taylor
▫Birdshot retinochoroidopathy differences in clinical characteristics with early and late age onset
Sukhum Silpa-archa, Jennifer H. Cao, Sutasinee Boonsopon, Joan Lee, Janine M. Preble Stephen Foster
▫Poor prognostic factors in patients with birdshot retinochoroidopathy
Sukhum Silpa-Archa, Joan J Lee, Sutasinee Boonsopon, Marisoll T, Lizarraga, Janine M Preble, Dusi Sujirarat, Pranav Patel, C Stephen Foster
▫Birdshot retinochoroidopathy: prognostic factors of long-term visual outcome
Sara Touhami, Christine Fardeau, Antoine Vanier, Olivia Zambrowski, Rafaela Steinborn, Claude Simon, Sophie Tezenas du Montcel, Bahram Bodghi, Phuc Le Hoang
There are several ‘quality of life’ questionnaires in existence that attempt to measure the effects of sight loss on mood and health. However, these questionnaires are not really relevant to the variable condition of birdshot uveitis with its many problems we face day to day, especially at the time of a flare or because of treatment side-effects. With the help of psychologist John Barry and ophthalmology consultant Professor Will Ayliffe, BUS designed a questionnaire for our membership to trial. In 2012, nearly 200 of our members completed this birdshot quality of life questionnaire as part of a study carried out by BUS to validate it. Below are links to the two papers that were published about this work:
▫Validation of a brief questionnaire measuring positive mindset in patients with uveitis
John A Barry, Annie Folkard, William Ayliffe
▫Development and validation of quality-of-life questionnaires for birdshot chorioretinopathy
John A Barry, Annie Folkard, Alastair K Denniston, Eileen Moran, William Ayliffe
Creating a Health Utility for Birdshot Chorioretinopathy
Anisha Sekaran , Mohith Shamdas , Robert J. Barry , Alastair K. Denniston & Philip I. Murray
▫“The patient is speaking”: discovering the patient voice in ophthalmology
Samera Dean, Jonathan M Mathers, Melanie Calvert, Derek G Kyte, Dolores Conroy, Annie Folkard, Sue Southworth, Philip I Murray, Alastair K Denniston
▫Controversies in the pharmacological treatment of uveitis
Robert J. Barry, Alastair K Denniston
▫Heterogeneity of primary outcome measures used in clinical trials of treatments for intermediate, posterior, and panuveitis
Alastair K Denniston, Gary N Holland, Andrej Kidess, Robert B Nussenblatt, Annabelle A. Okada, James T Rosenbaum, Andrew D Dick
Updated March 2022