We recently received details of some new research on birdshot from Jonas Kuiper and colleagues. Jonas says: ‘We’ve identified a new immune cell involved in birdshot which helps us better understand how the immune system’s communication gets mixed up in this condition. It also connects with the HLA-A29 and ERAP1/2 genes.’ This paper is not an easy read, but it shows how research is gradually uncovering what is going on in the many processes involved in birdshot.
Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy
Pulak R. Nath, Mary Maclean, Vijay Nagarajan, Jung Wha Lee, Mehmet Yakin, Aman Kumar, Hadi Nadali, Brian Schmidt, Koray D. Kaya, Shilpa Kodati, Alice Young, Rachel R. Caspi, Jonas J. W. Kuiper and H. Nida Sen